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Chemistry-heavy patent PDFs, turned into reviewable scientific evidence.

Jubust extracts exemplified compounds, assay results, and example-level disclosures from patent filings — each finding anchored to its exact source page. Every answer is inspectable. Nothing is assumed.

What scientists use Jubust for

The questions it answers.

These are not hypothetical — they map directly to the review workflows scientists run on competitor sets, patent families, and compound series. Every answer is backed by source citations you can inspect.

Today

What did they actually make and test — not just claim?

In this patent family or competitor set, which compounds were actually exemplified, what assays were run, what results were reported, and where exactly is that in the source? Jubust extracts exemplified compounds, assay data, and example-level disclosures — each one traceable to the source page.

Direct evidence extraction from patent text. Credible with current structured output.

Source passage · p.13

Example 1. To a 50 mL flask was added intermediate 3 (2.3 g, 8.5 mmol) in anhydrous DMF (20 mL) under N₂. The mixture was stirred at 60 °C for 18 h. After workup and silica gel purification, KD = 97.7 nM as determined by TR-FRET binding assay for KRas G12D. Fractions were pooled and concentrated under reduced pressure to afford the title compound as a white solid (1.1 g, 47% yield).

Extracted record

Verified

KRas G12D · KD

97.7nM
PDF p.2 · StructurePDF p.13 · Table 1 · KD
Today

What evidence across relevant patents should change our decision on this series or target?

Across the patents relevant to this target, mechanism, or compound series — what evidence supports or weakens a competitive or experimental decision? A structured review pack, not a summary. Every entry expandable back to patent source.

Supported by cross-patent evidence linking. No claim of exhaustive coverage or normalized assay comparisons.

KRas G12DAll assignees2021–2024Binding affinity
WO2021041671Ex 1KD 97.7 nMp.13
WO2022051443Ex 7KD 142 nMp.19
WO2023189012Ex 4IC₅₀ 68 nMp.8

3 compounds shown · 12 total for this target

Soon

Who is patenting compounds close to our lead series?

Which patents disclose chemistry structurally close to the series your team is working on — and what exactly did they show? This becomes available once extracted structures and scaffold linking are consistently good at scale.

Requires structural extraction at scale. Credible soon — not a current promise.

Query series

Query compound scaffold

KRas G12D scaffold

Close disclosures

WO2023041892

p.5

High

WO2022098763

p.12

Medium

Requires structural extraction at scale — available as evidence coverage grows.

From hard patent artifacts to reviewable evidence objects.

The bottleneck is not finding patent documents. It is reconstructing compounds, assay results, formulation details, and cross-page context quickly enough for real scientific decisions.

WO2021041671 · Ex 1Trace verified

KRas G12D KD

97.7nM
Compound structure

PDF p.2

Structure proof

PDF p.13

Table 1 · Row 1

Reviewable Evidence

Every important field stays linked to the exact source page and evidence region so a reviewer can confirm the claim instead of trusting a black-box answer.

p.2

Structure diagram

p.13

Table 1 · KD

p.47

Assay conditions

Example 1 · 97.7 nM · KRas G12D

3 sources linked

Cross-Artifact Linking

Jubust connects structures, assay tables, footnotes, and formulation context into coherent evidence packs instead of isolated extraction fragments.

Review queue

1 needs review

Compound

Target

Value

Status

Ex 1KRas G12D97.7 nMVerified
Ex 2KRas G12D142 nMVerified
Ex 7KRas G12CReview
Ex 12KRas G12D58 nMActive

Fast Expert Review

Confidence-aware routing and chemistry-aware checks help teams spend review time on the fields that matter, not on rebuilding every document from scratch.

Reviewable, not summarised

Every finding resolves back to its source page.

The workspace links compound structures, binding values, and assay context directly to the patent pages they came from. Click any citation badge to open the source. No black-box answers.

app.jubust.com/workspace/WO2021041671
WO2021041671·12 compoundsTrace verified
+7 more

Binding affinity · KRas G12D KD

97.7nM

IC₅₀ 114 nM · selectivity confirmed

Structure

Compound structure Example 1

Record fields

Compound

Example 1

Target

KRas G12D

Assay type

TR-FRET

Patent

WO2021041671

Filing date

Feb 2021

Source pages

p.2 + p.13

PDF p.2

Structure · anchor region

PDF p.13

Table 1 · Row 1 · KD

What the evidence enables

More evidence unlocks harder questions.

These use cases become credible once evidence is structured and linked at scale — the natural next layer above reviewed evidence packs.

Soon

What compound families are heating up around this target?

Which scaffold or compound families are seeing rising patent activity around this target or modality? Each trend row backed by the source patents underneath — not naked counts.

Scaffold familyRecent filings
KRas G12C covalent
8
SOS1 interface
6
KRas G12D non-covalent
5
KRAS-PPI disruptors
3

3 new filings in the past 90 days · Each row links to source patents

Soon

Which programs are starting to show cell, in vivo, or translational evidence — not just potency tables?

Which patent programs are moving beyond binding or potency claims into stronger biological or translational evidence? Evidence-type tracking, not quality assessment.

ProgramBindingCellularPK / in vivo
WO2021041671
WO2023189012
WO2022051443

Evidence type tracking only — does not imply scientific quality or program success.

Where this leads

A patent-native chemistry intelligence layer.

These are the questions worth asking once enough reviewable evidence is structured and linked. We are not there yet — but this is the direction that makes the current work worthwhile.

Later

Where are the underexplored regions worth reviewing next?

Which parts of this chemical neighborhood appear thinly covered by current patent literature — and which nearby patents are worth deeper investigation? Framed as exploration and hypothesis generation, not definitive white-space discovery.

Chemical space · KRas G12D

Covalent warhead variants7 patents · Low coverage
Non-covalent groove binders18 patents · Medium coverage
Switch II pocket29 patents · Well covered

Coverage reflects structured evidence only. Not a definitive prior-art landscape.

Later

What evidence links this scaffold, target, assay, and assignee across the field?

Navigate connected scientific evidence — how is this chemistry connected across patents, targets, assays, and companies? Every edge resolves back to source evidence. Not abstract network art.

SOS1/KRas G12D interface · non-covalent

Assays

  • TR-FRET
  • Biochemical displacement
  • Cellular viability

Assignees

  • Amgen
  • Mirati
  • Rev. Medicines

Patent families

  • WO2021041671
  • WO2023189012
  • WO2022051443
  • WO2020186101
  • WO2021252339
  • WO2022147188
  • WO2023034499

Each entity resolves to patent source evidence — not inferred relationships.

Questions & Answers

Evaluate Jubust on the patents your team actually reviews.

Bring the compounds, assay evidence, and competitive questions that matter to your team. We scope design-partner engagements around reviewable output, not generic demos.